Tag Archives: Disease From Animals

Dengue outbreak kills 300 in Sri Lanka, hospitals at limit

A mosquito landing on a person. Courtesy of Pixabay

COLOMBO (Reuters) – An outbreak of dengue virus has killed around 300 people so far this year in Sri Lanka and hospitals are stretched to capacity, health officials said on Monday.

They blamed recent monsoon rains and floods that have left pools of stagnant water and rotting rain-soaked trash — ideal breeding sites for mosquitoes that carry the virus.

The International Federation of Red Cross and Red Crescent Societies is scaling up emergency assistance to Sri Lanka with the Sri Lanka Red Cross to help contain the outbreak.

“Dengue patients are streaming into overcrowded hospitals that are stretched beyond capacity and struggling to cope, particularly in the country’s hardest hit western province,” Red Cross/Red Crescent said in a statement.

According to the World Health Organization, dengue is one of the world’s fastest growing diseases, endemic in 100 countries, with as many as 390 million infections annually. Early detection and treatment save lives when infections are severe, particularly for young children.

The Sri Lankan government is struggling to control the virus, which causes flu-like symptoms and can develop into the deadly hemorrhagic dengue fever.

The ministry of health said the number of dengue infections has climbed above 100,000 since the start of 2017, with 296 deaths.

“Ongoing downpours and worsening sanitation conditions raise concerns the disease will continue to spread,” Red Cross/Red Crescent said.

Its assistance comes a week after Australia announced programs to help control dengue fever in Sri Lanka.

“Dengue is endemic here, but one reason for the dramatic rise in cases is that the virus currently spreading has evolved and people lack the immunity to fight off the new strain,” Novil Wijesekara, head of health at the Sri Lanka Red Cross said in a statement.

(Reporting by Ranga Sirilal and Shihar Aneez Editing by Jeremy Gaunt.)

Alabama finds atypical mad cow case, no human threat seen

(Reuters) – An 11-year-old cow in Alabama tested positive for bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, the U.S. Department of Agriculture said on Tuesday.

The cow tested positive for the atypical L-type of BSE after exhibiting clinical signs at an Alabama livestock market, the USDA said in a press release. Atypical BSE can arise spontaneously in cattle herds, usually in animals 8 years old or older.

“This animal never entered slaughter channels and at no time presented a risk to the food supply, or to human health in the United States,” the USDA said. “Following delivery to the livestock market the cow later died at that location.”

The Alabama cow is the fifth detection of BSE in the United States, four of which were atypical.

“This finding of an atypical case will not change the negligible risk status of the United States, and should not lead to any trade issues,” the USDA added.

The only classical BSE case was an animal found in 2003 at a Washington farm that was imported from Canada and born before a 1997 ban on the use of cattle feed containing brain or spinal tissue, which can result in transmission of the disease.

China last month resumed imports of U.S. beef for the first time since banning them following the 2003 scare.

First detected in Britain in the 1980s, classical mad cow ravaged herds in parts of Europe until the early 2000s and was linked to the brain-wasting Creutzfeldt-Jakob disease in humans.

(Reporting by Michael Hirtzer; editing by Grant McCool)

WHO says India reports cases of Zika virus

FILE PHOTO: Aedes aegypti mosquitoes are seen inside Oxitec laboratory in Campinas, Brazil, on February 2, 2016. REUTERS/Paulo Whitaker/File Photo

NEW DELHI (Reuters) – India has reported cases of the Zika virus, the World Health Organization said, adding that efforts should be made to strengthen surveillance.

The WHO said that on May 15 India’s health ministry reported three confirmed cases from the western state of Gujarat. Cases were detected during testing in February and November last year, while one was detected in January this year, according to the statement, which was released on Friday but did not gain public attention until Saturday.

A federal health ministry official said states were following standard protocols and there was “nothing to worry” about. The ministry had in March cited one confirmed case of Zika – from January of this year in Gujarat – while answering a question in India’s parliament.

“These findings suggest low level transmission of Zika virus and new cases may occur in the future,” the WHO said in the statement on its website.

“Zika virus is known to be circulating in South-East Asia Region and these findings do not change the global risk assessment.”

In its most recent outbreak, Zika, which is mainly a mosquito-borne disease, was identified in Brazil in 2015 and has been spreading globally.

When the virus infects a pregnant woman, it can cause a variety of birth defects including microcephaly, where the baby’s head is abnormally small.

(Reporting by Aditya Kalra; Editing by Tom Lasseter and Andrew Bolton)

Scientists to test whether Zika can kill brain cancer cells

FILE PHOTO - Genetically modified male Aedes aegypti mosquitoes are pictured at Oxitec factory in Piracicaba, Brazil, October 26, 2016. REUTERS/Paulo Whitaker

By Kate Kelland

LONDON (Reuters) – Scientists in Britain plan to harness the Zika virus to try to kill brain tumor cells in experiments that they say could lead to new ways to fight an aggressive type of cancer.

The research will focus on glioblastoma, the most common form of brain cancer, which has a five-year survival rate of barely 5 percent.

Zika causes severe disability in babies by attacking developing stem cells in the brain – but in adults, whose brains are fully formed, it often causes no more than mild flu-like symptoms.

In glioblastoma, the cancer cells are similar to those in the developing brain, suggesting that the virus could be used to target them while sparing normal adult brain tissue.

Experts say existing treatments have to be given at low doses to avoid damaging healthy tissue.

Researchers led by Harry Bulstrode at Cambridge University will use tumor cells in the lab and in mice to assess Zika’s potential.

The mosquito-borne virus has spread to more than 60 countries and territories in a global outbreak that was first identified in Brazil in 2015.

“Zika virus infection in babies and children is a major global health concern, and the focus has been to discover more about the virus to find new possible treatments,” Bulstrode said in a statement.

“We’re taking a different approach, and want to use these new insights to see if the virus can be unleashed against one of the hardest-to-treat cancers …

“We hope to show that the Zika virus can slow down brain tumor growth in tests in the lab,” Bulstrode added. “If we can learn lessons from Zika’s ability to cross the blood-brain barrier and target brain stem cells selectively, we could be holding the key to future treatments.”

(Editing by Louise Ireland and Kevin Liffey)

U.S. Zika vaccine begins second phase of testing

FILE PHOTO: A pair of Aedes albopictus mosquitoes are seen during a mating ritual while the female feeds on a blood meal in a 2003 image from the Centers for Disease Control (CDC). REUTERS/Centers for Disease Control/James Gathany/Handout via Reuters

By Julie Steenhuysen

CHICAGO (Reuters) – Researchers have begun the second phase of testing of a Zika vaccine developed by U.S. government scientists in a trial that could yield preliminary results as early as the end of 2017.

Dr. Anthony Fauci, director of the National Institutes of Allergy and Infectious Diseases (NIAID), said on Friday the $100 million trial has already been funded and will proceed, irrespective of the $7 billion in cuts to the National Institutes of Health (NIH) budget proposed by the Trump Administration over the next 18 months.

In a conference call with reporters, Fauci would not comment on the proposed cuts because it is not clear yet what the actual budget will be. Both Democratic and Republican lawmakers oppose cuts to the NIH, which funds 21 institutes, including NIAID.

NIH Director Dr. Francis Collins is scheduled to speak with President Donald Trump later on Friday. “I will certainly be talking to Francis Collins when he returns from the White House,” Fauci said.

Zika typically causes mild symptoms, but when the virus infects a pregnant women, she can pass it to her fetus, causing a variety of birth defects including microcephaly, in which the baby’s head is abnormally small.

Fauci said the current Zika vaccine candidate had cleared preliminary safety hurdles, and would now enter testing for efficacy, which would occur in two phases.

The first phase will continue testing for safety and evaluate the vaccine’s ability to stimulate the immune system to develop antibodies to fight Zika. It will also test different doses to see which works best.

The second phase, set to begin in June, will attempt to determine if the vaccine can actually prevent Zika infection.

Several companies are developing Zika vaccines, including Sanofi SA, GlaxoSmithKline Plc and Takeda Pharmaceuticals.

In the NIAID study, researchers aim to enroll at least 2,490 healthy volunteers in areas with confirmed or potential active transmission of Zika by mosquitoes. These include parts of the continental United States, Puerto Rico, Brazil, Peru, Costa Rica, Panama and Mexico. They will receive either the vaccine, or a placebo, and be followed for two years.

If enough people are exposed to the virus, Fauci said they could get an effectiveness signal as early as the end of this year. The trial is expected to be completed by 2019.

Fauci said the government is already in discussions with pharmaceutical companies that would share the costs of the final stage of testing and handle manufacturing.

Zika is primarily transmitted by mosquitoes, but it can also be transmitted sexually. According to Centers for Disease Control and Prevention, 5,182 people in the continental United States have been infected by Zika either locally or through travel to places where the virus is spreading. Another 38,303 cases have been reported in U.S. territories, including Puerto Rico.

(Reporting by Julie Steenhuysen; editing by Diane Craft)

U.S.-UK alliance targets the world’s deadliest superbugs

MRSA (Methicillin-resistant Staphylococcus aureus) bacteria strain is seen in a petri dish containing agar jelly for bacterial culture in a microbiological laboratory in Berlin March 1, 2008. MRSA is a drug-resistant "superbug", which can cause deadly infections. REUTERS/Fabrizio Bensch

By Kate Kelland

LONDON (Reuters) – Eleven biotech companies and research teams in Britain and the United States were awarded up to $48 million in funding on Thursday to speed development of new antibiotics powerful enough to take on the world’s deadliest superbugs.

The range of antimicrobial medicines able to kill the growing number of drug-resistant infections is dwindling and health experts warn that within a generation the death toll from such “superbug” infections could reach 10 billion.

Announcing its first funding, a new U.S.-U.K. alliance known as CARB-X, short for Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator, said it would invest an initial $24 million in 11 biotech companies pursing various projects to develop antibiotics and diagnostic. Another $24 million will be given in staged payments over three years as projects progress.

Added to private funds from the companies, the CARB-X funding could lead to an investment of more than $75 million in projects that show success, it said in a statement. Britain’s Wellcome Trust global health charity is committing 125 million pounds ($155.5 million) over five years.

Public health specialists have been warning for years that the world is facing an urgent global health threat from antibiotic-resistant superbug bacteria and that the pipeline of novel therapies to treat them is precariously thin.

Drug-resistant infections kill 700,000 people a year worldwide, and the last new antibiotic class to be approved for market was discovered in 1984.

With CARB-X funds, three of the 11 projects are working on potential new classes of antibiotics, while four are exploring new ways of targeting and killing bacteria.

Tim Jinks, head of drug resistant infection at the Wellcome Trust, said antibiotic resistance is already “a huge global health challenge” and is getting worse. “Without effective drugs, doctors cannot treat patients,” he said in a statement.

Kevin Outterson, CARB-X’s executive director and a professor of law at Boston University in the United States, added: “By accelerating promising research, it is our hope that we can speed up the delivery of new effective antibacterials, vaccines, devices and rapid diagnostics to patients who need them.”

(Editing by Alexander Smith)

Top U.S. chicken producing state suffers first case of bird flu

quarantine researcher checking chickens on poultry farm for bird flu

By Tom Polansek

CHICAGO (Reuters) – Georgia has confirmed its first-ever case of bird flu in commercial poultry, its agriculture department said on Monday, widening an outbreak of the disease into the United States’ biggest chicken meat-producing state.

A flock of 18,000 chickens used for breeding was culled after testing positive for H7 bird flu, according to the agriculture department. It said the birds in far northwestern Georgia were likely infected with a form of the virus that is not highly lethal because the flock did not show signs of illness.

The discovery came after officials in Alabama, Kentucky and Tennessee confirmed cases of highly pathogenic, or lethal, and low pathogenic H7N9 bird flu in breeding operations this month. U.S. officials have said the risk of the disease spreading to people from poultry or making food unsafe is low.

But the spread of highly pathogenic bird flu to poultry in new states would represent a financial risk for meat companies because it could kill more birds or require flocks to be culled. It could also trigger more import bans from other countries after South Korea and other buyers limited U.S. poultry shipments following highly pathogenic cases in Tennessee.

The worst-ever U.S. outbreak of highly pathogenic bird flu in poultry in 2014 and 2015 killed about 50 million birds, most of which were egg-laying hens in Iowa.

More than 200,000 breeding chickens in Georgia, Alabama, Tennessee and Kentucky have been killed in recent weeks by high and low pathogenic bird flu or culled to contain the virus, according to state officials. U.S. poultry producers had about 55.1 million breeder hens on hand as of March 1, according to the USDA.

In 2015, Georgia produced 7.9 billion pounds of chicken meat valued at $4.2 billion, the agency said.

“Poultry is the top sector of our number one industry, agriculture, and we are committed to protecting the livelihoods of the many farm families that are dependent on it,” Gary Black, Georgia’s agriculture commissioner, said in a statement.

Some companies are still feeling pressure related to the 2015 losses.

On Monday, Cal-Maine Foods, the biggest U.S. egg producer, said its quarterly sales fell about 32 percent from a year ago because prices were under pressure after farmers increased production in response to an outbreak two years ago.

(Reporting by Tom Polansek; Editing by Andrew Hay)

Alabama waits for U.S. verdict on bird flu; importers limit trade

By Tom Polansek

CHICAGO (Reuters) – U.S. trading partners on Friday limited shipments of poultry from Alabama, a top producer of chickens for meat, over bird flu concerns as the state’s wait for federal confirmation of two suspected cases stretched past a week.

The European Union, Kazakhstan and French Polynesia restricted shipments from Alabama counties with presumed cases of the disease, according to the U.S. Department of Agriculture’s website. The moves came a day after the state reported the agency’s national animal-health laboratories had confirmed a separate case of bird flu there.

Belarus blocked shipments from the entire state.

Alabama officials and poultry producers have been waiting since March 8 for the National Veterinary Services Laboratories (NVSL) to confirm the two suspected cases, which involve a commercial chicken farm and a backyard flock, according to the state. The facility in Ames, Iowa, is the only one in the United States that officially confirms cases of avian flu.

Swift confirmation is important for U.S. trading partners, some of which restrict shipments from geographic areas with infected flocks, and for state officials, who want to know which strain of the virus they are battling.

Highly pathogenic, or lethal, bird flu led to the deaths of about 50 million birds, mostly egg-laying hens, in the United States in 2014 and 2015.

Another widespread outbreak could be a financial blow for poultry operators, such as Tyson Foods Inc or Pilgrim’s Pride Corp, because it could kill more birds or require flocks to be culled.

The national labs must determine the strain and pathogenicity of the disease in order to officially confirm an infection, according to the USDA. The process often takes just a day.

A rapid test can be made when poultry samples contain sufficient genetic material, USDA spokeswoman Lyndsay Cole said on Thursday. But the samples from Alabama’s two suspected cases contained low levels, meaning scientists had to start a testing process that can take 14 days, she said.

Tests by a USDA-approved lab in Alabama and the national labs have already identified the H7 subtype of the virus from samples in the two suspected cases, she said.

“Our department respects the science behind the testing and is patiently waiting for accurate results,” said Amy Belcher, spokeswoman for Alabama’s agriculture department.

Alabama authorities presume the suspected cases are not highly lethal, or pathogenic, bird flu because the animals did not show signs of being sick. Still, officials have been checking birds at nearby farms for infections and the owners of the suspect flocks culled the birds, according to Alabama’s state veterinarian.

The United States must alert the World Organisation for Animal Health (OIE) if Alabama’s suspected cases are confirmed as positive, a step that could trigger more trade restrictions.

The OIE said “it is more important for the laboratory to be sure of its analysis than to be fast with it.”

(Additional reporting by Sybille de La Hamaide in Paris; Editing by Matthew Lewis)

Bird flu hits another U.S. farm that supplies Tyson Foods

quarantine researcher checking chickens on poultry farm for bird flu

By Tom Polansek

CHICAGO (Reuters) – Bird flu that is highly lethal to poultry has infected a second commercial chicken farm in Tennessee that supplies Tyson Foods Inc, company and state officials said on Thursday.

The finding expands an outbreak near the major chicken-producing states of Alabama and Georgia, and is the second in the type of breeder flock crucial for keeping the chicken-meat industry supplied with birds. A case of less dangerous bird flu was confirmed in Alabama on Thursday.

In Tennessee, authorities have started to cull the infected flock of 55,000 chickens in Lincoln County, to contain the highly pathogenic H7N9 flu, according to the U.S. Department of Agriculture.

The farm was in a quarantine zone established after authorities this month found the same strain of the disease in a flock of about 73,500 chickens less than 2 miles (3.2 km) away, the Tennessee Department of Agriculture said. That farm also supplied Tyson, the world’s biggest chicken company.

“I’m sure on the part of the company they’re quite concerned and going back and reviewing all of their information and data to determine how in the world this got into the buildings,” said Bret Marsh, state veterinarian in Indiana, which had the nation’s only highly pathogenic bird flu case in poultry in 2016.

The initial case in Tennessee was the nation’s first infection of highly pathogenic bird flu at a commercial operation in more than a year. Tennessee also recently detected a less-dangerous case of low-pathogenic flu in another chicken flock.

On Thursday, Alabama said the USDA confirmed a suspected case of low-pathogenic flu in a guinea fowl at a flea market as H7N9. Aviagen, the world’s largest poultry breeding company, has culled chickens in the state over concerns about the disease.

Highly pathogenic bird flu led to the deaths of about 50 million birds, mostly egg-laying hens, in the United States in 2014 and 2015.

Another widespread outbreak could represent a financial blow for poultry operators because it could kill more birds or require flocks to be culled. It also would likely trigger more import bans from trading partners, after South Korea, Japan and other countries limited imports after the first highly pathogenic case in Tennessee.

China has also been grappling with an outbreak of H7N9, which has killed 161 people since October. U.S. authorities have said that strain is genetically distinct from the H7N9 in Tennessee and that the risk of the disease spreading to people from poultry or making food unsafe is low.

Tyson said it worked with Tennessee and federal officials to quickly euthanize birds in the infected flock and did not expect disruptions to its chicken supply.

“Our business is diversified and scaled across multiple states, so we plan to meet our customers’ needs,” spokesman Worth Sparkman said.

Tyson shares fell 1.7 percent to close at $62.00 on Thursday.

The company has said it tests all the birds it owns for the virus and flocks diagnosed with highly pathogenic flu are not processed.

Wild birds can carry the disease without showing signs of sickness and transmit it to poultry through feces, feathers or other forms of contract.

(Editing by Chizu Nomiyama and Matthew Lewis)

Poultry breeder Aviagen culls U.S. flock over bird flu fears

FILE PHOTO: The Avian influenza virus is harvested from a chicken egg as part of a diagnostic process in this undated U.S. Department of Agriculture (USDA) handout image. Erica Spackman/USDA/Handout/File Photo via REUTERS

By Tom Polansek

CHICAGO (Reuters) – Aviagen [EWESJA.UL], the world’s leading poultry breeding company, has euthanized chickens at a farm in Alabama over concerns about bird flu, the company said on Tuesday, as likely cases of the disease emerged in a top chicken-producing state.

Alabama officials said they suspected that poultry at three sites in the state were infected with the virus, about a week after some 90,500 chickens were culled over infections at two commercial operations across the border in Tennessee.

Aviagen detected the presence of antibodies for the flu virus in a flock in Alabama that showed “no evidence of clinical disease,” company spokeswoman Marla Robinson said in an email. The company is based in Alabama.

The company euthanized the flock and “all eggs which were collected from that farm in the production system were traced and removed,” she said. Aviagen did not respond to a question about how many birds were killed.

Tony Frazier, Alabama’s state veterinarian, said the company chose to cull about 15,000 birds. The U.S. Department of Agriculture (USDA) said the farm had 153,000 birds.

A national USDA lab is testing samples from poultry in Alabama to identify the strain of the virus and how lethal it is for birds, after another agency-approved lab identified the H7 subtype of the disease in samples, USDA spokeswoman Lyndsay Cole said.

The birds in Alabama did not show clinical signs of sickness, which indicates they did not have a highly lethal, or pathogenic, form of the virus, Cole said.

In Tennessee, both cases were identified as H7N9. The USDA on March 5 confirmed that one was the United States’ first infection of highly pathogenic flu in commercial poultry in a year. Days later, the state said it had found the other case nearby and it was low pathogenic.

Highly pathogenic bird flu led to the deaths of about 50 million birds, mostly egg-laying hens, in the United States in 2014 and 2015.

Another highly pathogenic outbreak would likely represent a financial blow for poultry operators such as Tyson Foods Inc and Pilgrim’s Pride Corp because it would kill more birds or require flocks to be culled.

It also would likely trigger more import bans from trading partners, after South Korea, Japan and other countries limited imports after the highly pathogenic case in Tennessee.

Health officials have said the risk of bird flu spreading to people from poultry or making food unsafe was low.

Separately, Frazier said the owner of a backyard flock suspected of having the virus chose to cull about 70 birds. No poultry linked to the third suspected case, which involved birds at a flea market, have been culled, he said.

Frazier said the cases were still only suspected flu infections and needed to be confirmed by the USDA. Earlier, the Alabama Department of Agriculture and Industries called a news conference to discuss what it said were three findings of avian influenza.

Alabama raised more than 1 billion chickens for meat in 2015, making it the country’s third largest producer, according to the USDA.

The national USDA laboratory, to which samples from the state were sent, is the only one in the United States that officially confirms cases.

The World Organization for Animal Health requires that all confirmed low-pathogenic H5 and H7 bird flu subtypes be reported because of their potential to mutate into highly pathogenic strains. Highly pathogenic cases also must be reported.

(Reporting by Tom Polansek; Editing by Frances Kerry, Toni Reinhold)