AstraZeneca commits to 1.8 million Thai vaccine doses amid supply anxiety

By Patpicha Tanakasempipat

BANGKOK (Reuters) – Drugmaker AstraZeneca said on Wednesday it would soon provide Thailand with 1.8 million doses of locally manufactured COVID-19 vaccine, the first of multiple batches this month, just days away from the launch of the country’s vaccination drive.

The joint announcement by AstraZeneca and Siam Bioscience, a firm owned by Thailand’s king, comes amid public anxiety about vaccine supplies, as the country suffers its most severe outbreak so far.

It did not say whether the Thai plant would make all 6 million doses that Thailand’s government has promised would be available this month.

The government’s mass immunization drive starts on Monday and relies almost entirely on its reserved 61 million doses of AstraZeneca vaccine, most of which it said would come from Siam Bioscience, which is making vaccines for the first time.

Questions about Siam Bioscience meeting production targets are sensitive because King Maha Vajiralongkorn is its sole owner. Insulting Thailand’s monarchy is a crime punishable by up to 15 years in prison.

AstraZeneca has partnered with the Thai firm for the manufacture of 200 million doses for use in Southeast Asia, a region with low COVID-19 immunization rates that is seeing a strong resurgence of the virus.

Thailand is seeking 100 million doses of coronavirus vaccine this year in total.

Thai health minister Anutin Charnvirakul said on Wednesday the promised 6 million doses would come this month “as planned”, but specified no delivery dates or the number to be sourced locally.

Anutin also said Thailand will get an additional 11 million doses of Sinovac vaccines before August. Thailand has used the Chinese vaccine for most of its early inoculations of frontline workers.

“We will get AstraZeneca vaccine. It may come from wherever, but all AstraZeneca just the same. It could be made in Thailand or imported from overseas. It depends on AstraZeneca’s supply chain,” Anutin told reporters.

Siam Bioscience has not answered queries from Reuters on its production targets.

AstraZeneca said 1.8 million locally produced doses would be delivered by Monday, the first of multiple deliveries this month.

It said deliveries of Thai-made doses to other Southeast Asian countries would start in July.

The first delivery to the Philippines, which was promised 17 million doses, was cut from 1.3 to 1.17 million doses and delayed from late June to mid-July, a Philippine presidential advisor told Reuters on Tuesday, citing Thai production delays.

(Reporting by Patpicha Tanakasempipat; Additional reporting by Panarat Thepgumpanat and Panu Wongcha-um; Editing by Martin Petty)

Ontario issues stay-at-home order, closes most stores as COVID cases rise

(Reuters) -Ontario will begin a four week-long stay-at-home order and close in-store shopping for non-essential retailers as of Thursday, Premier Doug Ford said on Wednesday, as the Canadian province battles a surge of COVID-19 cases.

“The situation is extremely serious. We need to hunker down right now,” Ford said at a briefing in Toronto.

“What we do until we start achieving mass immunization will be the difference between life and death for thousands of people.”

The order requires people in Canada’s most populous province to stay in their residences except for essential reasons, including exercise, vaccination appointments or grocery trips.

Last week, Ontario shuttered all indoor and outdoor dining, a move that fell short of what the government’s expert advisory panel said was necessary to avoid catastrophically high case numbers.

All retailers except those selling grocery, pharmacy and gardening goods will close for four weeks, except for curbside pickup. Big box stores can remain open, but with capacity limits and only certain products including groceries, pharmacy and gardening materials available for in-store purchase.

Industry groups had criticized Ford for allowing big box stores to remain open during past lockdowns while shutting small businesses.

Retailers considered essential can open for in-store shopping by appointment only. These include medical device supply and repair shops, optical stores and auto mechanics.

On Tuesday, Canada reported 6,520 cases, the most recent data publicly available. Prime Minister Justin Trudeau warned of a “very serious” third wave of the virus, with more young people going into hospital and on ventilators due to more lethal variants.

Hospitals in Ontario are becoming more stretched. Provincial data showed more COVID-19 patients in intensive care units than at any point since the pandemic began.

ICU admissions are rising faster than the worst-case scenario modelled by experts, Ford said.

The province also announced that all teachers and education staff in Toronto and the suburb of Peel would be eligible for vaccination beginning during the school districts’ April break.

On Tuesday Toronto Public Health shuttered the city’s schools for in-person learning, sending the country’s largest school district of around 247,000 students back to remote learning from Wednesday until April 18.

Hours earlier Ford had told reporters that schools were safe and closures would be unnecessary.

Ontario reported 3,215 new cases on Wednesday, according to government data.

(Reporting by Moira Warburton in Vancouver Editing by Chris Reese and David Gregorio)

U.S. tops 10 million COVID vaccinations as California expands eligibility for shots

By Peter Szekely and Dan Whitcomb

(Reuters) – More than 10 million Americans had received their first dose of a COVID-19 vaccine as of Wednesday, according to the U.S. Centers for Disease Control and Prevention, as the year-old pandemic roared on unchecked.

The United States reached 10.2 million inoculations one day after the CDC and Trump administration gave new guidance to U.S. states on who should receive the shots first. Strict rules putting healthcare workers first in line had slowed the rollout. Now states are urged to vaccinate anyone over 65 as well.

California moved on Wednesday to do just that, designating all individuals 65 and older eligible to begin receiving vaccines, adding 6.6 million people to the rolls of those qualified to be immunized, Governor Gavin Newsom said.

The move bumps senior citizens, regardless of whether they have underlying medical conditions, to the top of the priority list for vaccine recipients, just behind front-line healthcare workers and residents and staff of nursing homes.

California, like many states, has struggled to use up as much vaccine as it received in initial allotments from the federal government, administering only about a third of the nearly 2.5 million doses shipped to the state as of Monday.

Newsom has set a goal of inoculating 1 million more Californians by the end of this week with the first shot of the two-dose vaccine.

He also said the state would launch a new system next week for notifying people when they become eligible for the vaccine, and to register for notification by email or text.

The latest push to spur the most ambitious mass immunization campaign in U.S. history came as the nation set a new record for coronavirus deaths in one day, with 4,336 fatalities on Tuesday, according to a Reuters tally.

Health and Human Services Secretary Alex Azar on Tuesday said the administration was releasing its full stockpile of two vaccines approved for emergency use, including some that had been held in reserve to make sure that second doses could be given on schedule.

Nearly 30 million doses of the vaccines, manufactured by Moderna and Pfizer with its German partner BioNTech, have been released to U.S. states, which have used only about one-third of them.

Johnson & Johnson said on Wednesday that the pharmaceutical company was on track to roll out its single-shot vaccine in March.

In an interview with Reuters on Tuesday, Dr. Paul Stoffels also said J&J expected to meet its stated target of delivering 1 billion doses of its vaccine by the end of this year as the company ramps up production.

Political leaders and health officials nationwide have scrambled in recent days to push out more vaccines to their residents, many lowering the age requirement to 65. California and New York have both pledged to inoculate one million residents this month.

NEW YORK SEEKS MORE VACCINE

In New York City, Mayor Bill de Blasio, a Democrat, said on Wednesday that short supplies of the vaccine could hamper efforts to reach the city’s inoculation goals.

“We need the federal government, the state government and the manufacturers to step up and get us more supply immediately,” de Blasio told a news conference.

The nation’s most populous city is adding vaccination sites across its five boroughs, including its two Major League Baseball stadiums.

“I confirmed with our healthcare team yesterday that even with normal supplies that we expect to have delivered next week, we will run out of vaccine at some point next week, unless we get a major new resupply,” de Blasio said.

Public health officials say so far no U.S. state has used up its supply of the vaccines.

At the Javits Center in Manhattan, which was pressed into service as a temporary hospital in April, health officials said they were prepared to vaccinate 10,000 people in 12 hours, with the ability to ramp up to 25,000 in a 24-hour period.

New York has recorded nearly 40,000 coronavirus fatalities since the pandemic broke out there in March, more than any other U.S. state.

Nationwide more than 380,000 people have died of COVID-19. A total of 22.7 million have been infected during that time.

The number of COVID-19 patients requiring hospitalization may have leveled off at least temporarily, according to a Reuters tally, although public health officials warned that further spread may still be seen from holiday gatherings.

California, the nation’s most populous state, has seen new hospitalizations drop this week, according to health officials. More than 30,000 Californians have so far died of COVID-19 related illness.

The recent emergence of a more infectious variant of the virus first seen in the United Kingdom has made efforts to accelerate vaccinations all the more important. The so-called UK variant has so far been confirmed in at least 10 U.S. states.

(Reporting by Peter Szekely and Andrew Hofstetter in New York, Julie Steenhuysen in Chicago and Dan Whitcomb and Steve Gorman in Los Angeles; Editing by Cynthia Osterman, Alistair Bell and Catherine Evans)